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Filtered Search Results
Apexbio Technology LLC Methacholine chloride 62-51-1 200mg
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Methacholine chloride (CAS 62-51-1) is a synthetic choline ester that selectively activates muscarinic acetylcholine receptors predominantly the M3 subtype on airway smooth muscle cells By stimulating these receptors it induces bronchoconstriction and airway narrowing mimicking pathophysiological responses observed in airway hyperreactivity Methacholine chloride is frequently utilized in research to assess bronchial hyperresponsiveness (BHR) and measure airway hyperreactivity (AHR) in experimental models Clinically it supports the evaluation of asthma-like symptoms in patients with normal baseline pulmonary function
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TARGETMOL CHEMICALS INC Triclabendazole 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease. Purity 98.35%
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TARGETMOL CHEMICALS INC OROTIRELIN 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Orotirelin(CG 3509) a thyrotropin-releasing hormone analog reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia. purity: 100%
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Medchemexpress LLC 5-(furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide | 909089-13-0 | MFCD14733081 | 99.7% | 286.29 g/mol | C14H14N4O3 | 200 MG
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SKL2001 is a small-molecule agonist of the Wnt/β-catenin signaling pathway used in biomedical research. It stabilizes intracellular β-catenin by disrupting the Axin/β-catenin interaction and has reported anti-cancer activity. The compound is supplied as a high-purity solid and exhibits high solubility in DMSO, with available protocols for in vivo formulation.
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Apexbio Technology LLC GDC-0941 957054-30-7 200mg
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GDC-0941 (CAS 957054-30-7) is a selective small-molecule inhibitor of class I phosphoinositide 3-kinase (PI3K) a critical component involved in the PI3K/Akt signaling pathway frequently dysregulated in cancer By competitively binding to the ATP-binding site of PI3K GDC-0941 inhibits generation of the downstream signaling molecule phosphatidylinositol-3 4 5-trisphosphate (PIP3) Exhibiting high selectivity against p110 / (IC50 approx 3 nM) and moderate selectivity for p110 (33 nM) and p110 (75 nM) GDC-0941 has demonstrated antiproliferative activity across diverse tumor cell lines in vitro (e g A2780 PC3 U87MG) and tumor growth inhibition in xenograft cancer models supporting its utility in cancer research
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Medchemexpress LLC Sulfo-Cy5 maleimide | 2130955-10-9 | 92.9% | 764.91 | C38H44N4O9S2 | 10 MG
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Sulfo-Cy5 maleimide is a sulfonated Cyanine-5 maleimide fluorescent dye that selectively labels thiol groups via a stable thioether linkage, enabling covalent protein and antibody conjugation for imaging and assays. It is water-soluble and optimized for far-red fluorescence detection in biochemical and cell-based applications.
- Thiol-selective maleimide for covalent protein labeling.
- Far-red Cy5 fluorescence suitable for imaging and detection.
- Water-soluble sulfonated structure improves aqueous compatibility.
- Soluble in DMSO at about 125 mg/mL (163.42 mM); ultrasonic assistance recommended; use freshly opened DMSO.
- Purity approximately 92.9% and molecular weight ≈764.91 g/mol.
- Store protected from light at 4°C; in solution keep at -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC Mivavotinib monohydrochloride | 1952251-28-3 | 99.5% | 380.85 | C17H22ClFN6O | 10 MG
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Mivavotinib monohydrochloride is the hydrochloride salt of mivavotinib, a potent, selective, reversible dual inhibitor of spleen tyrosine kinase (SYK) and fms-related tyrosine kinase 3 (FLT3) used for preclinical research. Supplied as a high-purity research chemical, it is used to probe SYK/FLT3 signaling and antitumor activity.
- Potent dual SYK and FLT3 inhibition, with reported IC50 values of 3.2 nM and 4.6 nM.
- High purity suitable for research (data sheet reported 99.50%).
- Available in small milligram pack sizes for preclinical experiments.
- Monohydrochloride salt form for improved stability and solubility compared with the free base.
- Molecular weight 380.85 and formula C17H22ClFN6O for accurate dosing calculations.
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Apexbio Technology LLC Phenanthrene 85-01-8 200mg
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Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) that exerts its biological activity primarily through the induction of cellular inflammatory responses enhancement of reactive oxygen species (ROS) generation and activation of apoptotic signaling pathways Based on these pharmacological properties phenanthrene is utilized in research to study PAH-induced cellular toxicity oxidative stress mechanisms and programmed cell death pathways Additionally it serves as a representative analyte in environmental toxicology investigations to detect quantify and evaluate PAH contamination in water and soil supporting the development of toxicological evaluation models and detection methods
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eMolecules Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3
Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3
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Apexbio Technology LLC Semagacestat (LY450139) 425386-60-3 200mg
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Semagacestat (LY450139 CAS 425386-60-3) is a gamma-secretase inhibitor belonging to the azadecalin class investigated for its potential in Alzheimer s disease research By selectively inhibiting gamma-secretase Semagacestat decreases the production rate of beta-amyloid (A ) peptides in both animal models (including mice beagle dogs and guinea pigs) and human subjects A is a principal component of amyloid plaques observed in the brains of Alzheimer s patients In transgenic mouse models expressing mutant human amyloid precursor protein (APP V717F) Semagacestat has been shown to slow A accumulation in the brain and reduce amyloid plaque burden dose-dependently supporting its utility as a tool compound in Alzheimer s disease pathogenesis studies
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Apexbio Technology LLC NPS-2143 284035-33-2 200mg
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NPS-2143 (CAS 284035-33-2) is a selective antagonist of the calcium-sensing receptor (CaSR) It attenuates the sensitivity of CaSR to extracellular calcium ([Ca2 ]o) thereby modulating downstream signaling and promoting parathyroid hormone (PTH) secretion in vivo In vitro studies demonstrate that NPS-2143 inhibits [Ca2 ]o-induced intracellular calcium signaling in HEK 293T cells expressing CaSR with an EC50 of 4 27 mM for the wild-type receptor It also reduces excessive signal transduction in cells expressing various activating CaSR mutations NPS-2143 is widely utilized in research investigating CaSR function calcium homeostasis and the pharmacological modulation of parathyroid hormone regulation
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eMolecules JW PharmLab LLC / 5-Amino-pyrazine-2-carboxylic acid ethyl ester / 500mg / 571064491 / 70R0064 / 97.000 / 54013-06-8 / MFCD08437665 / 167.168 / C7H9N3O2
JW PharmLab LLC / 5-Amino-pyrazine-2-carboxylic acid ethyl ester / 500mg / 571064491 / 70R0064 / 97.000 / 54013-06-8 / MFCD08437665 / 167.168 / C7H9N3O2
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Medchemexpress LLC Firmonertinib mesylate | 2130958-55-1 | 99.9% | 664.70 | 25 MG
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Firmonertinib mesylate is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations and the T790M acquired resistant mutation. This compound has potential for research into cancer diseases, particularly advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations
- Inhibits T790M acquired resistant mutation
- Potential for research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation
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TARGETMOL CHEMICALS INC KB-R7943 MESYLATE 25MG
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Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 uM. purity: 99%
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Medchemexpress LLC Dosimertinib-d5 mesylate | 2403760-72-3 | 99.4% | C29H32D5N7O5S | 10MG
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Dosimertinib-d5 mesylate is the deuterated mesylate salt of dosimertinib, a third-generation epidermal growth factor receptor (EGFR) inhibitor. Provided as a research-grade reference standard for preclinical and analytical applications; not for human or veterinary use.
- Deuterated internal standard for analytical assays and mass spectrometry.
- High purity: 99.4%.
- Molecular formula: C29H32D5N7O5S.
- Available in small pack sizes (1-100 mg) suitable for method development.
- Mesylate salt form for improved handling and stability.
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